FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF BISOPROLOL FUMARATE FOR THE TREATMENT OF HYPERTENSION

Abstract

Bisoprolol fumarate is a selective β1-blocker used in the treatment of hypertension. The present study focuses on the formulation and evaluation of sublingual tablets to provide rapid onset of action and avoid first-pass metabolism. Tablets were prepared by direct compression using suitable superdisintegrants. The formulations were evaluated for pre- and post-compression parameters such as flow properties, hardness, friability, drug content, wetting time, and disintegration time. All formulations showed acceptable results within pharmacopeial limits. The optimized batch exhibited rapid disintegration and faster drug release in dissolution studies, indicating improved bioavailability. Thus, sublingual tablets of bisoprolol fumarate offer an effective alternative to conventional oral dosage forms for quick management of hypertension..